Individuals without DS exhibited significant improvement in cognitive function following exercise (p<0.05). Exercise did not alter the cognitive function (p>0.05) or mMCAv (p>0.05) in individuals with DS. Cognitive function and CBF characteristics were measured before, immediately after, and 30 minutes following a 20 minute bout of moderate intensity treadmill walking.Ĭognitive function was significantly lower (p0.05). We further investigated the effects of a single bout of moderate intensity aerobic exercise on cognitive function and CBF in these individuals. Thus, we investigated the difference in cognitive function and CBF and its relationship in individuals with and without DS. However, it is unknown if the cerebral blood flow (CBF) characteristics are related to cognitive function in individuals with DS at rest and post exercise. Cognitive function is related to brain perfusion, with higher pulsatile blood flow having a detrimental effect on brain microvasculature.Įxercise can improve cerebral blood flow and cognitive function in individuals without DS. Cognitive decline with dementia and AD hinders not only the wellbeing of individuals with DS, but also the independence of the aging population with DS. Down syndrome (DS), the leading genetic condition of intellectual disability, is associated with high risk of cognitive decline, dementia, and Alzheimer’s disease (AD).
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